Epoetin-Induced Autoimmune Pure Red Cell Aplasia
نویسندگان
چکیده
منابع مشابه
Epoetin-induced autoimmune pure red cell aplasia.
During the first 10 yr of therapy with recombinant human erythropoietin ([EPO]), only three cases of antibody-associated pure red cell aplasia have been described in patients who were treated with EPO, whereas several millions of patients have received this treatment. Thus, the possibility for epoetin to induce the formation of anti-EPO antibodies was considered extremely low. However, since 19...
متن کاملPure red cell aplasia induced by epoetin zeta
Pure red cell aplasia (PRCA) may develop in patients with chronic kidney disease receiving erythropoiesis-stimulating agents (ESA). We report on a 72-year-old patient who developed hypo-proliferative anaemia unresponsive to ESA following the administration of epoetin zeta subcutaneously for 7 months. On the basis of severe isolated hypoplasia of the erythroid line in the bone marrow and high-ti...
متن کاملEpoetin alfa (Eprex): reports of pure red blood cell aplasia.
© 2002 Canadian Medical Association or its licensors Reason for posting: Health Canada has alerted health care professionals of a letter issued by Janssen-Ortho Inc. warning of serious postmarketing adverse events associated with the anemia drug epoetin alfa (Eprex). Seven cases of pure red cell aplasia (PRCA) have been reported in Canada after an estimated 80 000 patient-years of exposure to t...
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Long-term administration of azathioprine is widely used to prevent rejection in organ transplantation and in the treatment of autoimmune diseases. Bone marrow toxicity is a well-known side-effect of azathioprine. Macrocytosis, with or without megaloblastic erythropoiesis in the bone marrow, and (mild) leukopenia are frequently seen [1-4]. Less common effects are anaemia, thrombocytopenia and pa...
متن کاملDiphenylhydantoin-induced pure red cell aplasia.
Pure red cell aplasia is an uncommon complication of diphenylhydantoin therapy. It has not been reported in Indian literature. Awareness of the entity helps in establishing the cause of anaemia in these patients and alerts the physicians to the need of comprehensive haematological monitoring in these patients. A case of 58-year-old male who developed pure red cell aplasia following three months...
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ژورنال
عنوان ژورنال: Journal of the American Society of Nephrology
سال: 2005
ISSN: 1046-6673,1533-3450
DOI: 10.1681/asn.2004110959